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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PLK1 All Species: 24.85
Human Site: T341 Identified Species: 34.17
UniProt: P53350 Number Species: 16
    Phosphosite Substitution
    Charge Score: -0.06
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P53350 NP_005021.2 603 68255 T341 P S N R K P L T V L N K G L E
Chimpanzee Pan troglodytes XP_001163623 603 68223 T341 P S T R K P L T V L N K G L E
Rhesus Macaque Macaca mulatta XP_001092070 603 68240 T341 P S N R K P L T V L N K G L E
Dog Lupus familis XP_547091 832 93293 T569 P S N R K P L T V L N K G T E
Cat Felis silvestris
Mouse Mus musculus Q07832 603 68282 K341 P S S R K P L K V L N K G V E
Rat Rattus norvegicus Q62673 603 68295 T341 P S N R K P L T V L N K G V E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505317 482 55166 E238 E K V P E K E E A A P R E Q G
Chicken Gallus gallus NP_001025810 595 66904 T331 L N G R K P L T A L N K G P E
Frog Xenopus laevis P70032 598 68193 T332 Q S L R K P L T A I N K G Q D
Zebra Danio Brachydanio rerio NP_001003890 595 67743 L327 P A L L R K P L S S L N K G T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P52304 576 66955 M313 S M H R K P L M E M N G I R P
Honey Bee Apis mellifera XP_396707 575 66141 N311 R K P L S E M N T N V G G E G
Nematode Worm Caenorhab. elegans P34331 649 73615 G326 E E N V A P R G V D A R S Q R
Sea Urchin Strong. purpuratus XP_784826 587 66895 G315 R P L L E V N G Q D E N V P P
Poplar Tree Populus trichocarpa
Maize Zea mays P0C8M8 626 70215 S324 Q F A S P E N S V K V P S Q P
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9STV4 445 50410 L201 C G V I L Y V L M A G Y L P F
Baker's Yeast Sacchar. cerevisiae P32562 705 81013 K369 E Q S L V N F K D C M E K S L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.8 99.8 69.5 N.A. 95 94.1 N.A. 69.3 80 79.7 74.3 N.A. 50.7 51.4 49.9 59.3
Protein Similarity: 100 99.8 99.8 71 N.A. 97.6 96.8 N.A. 74.7 89.8 90.5 87.5 N.A. 69.4 69.9 66.2 76.4
P-Site Identity: 100 93.3 100 93.3 N.A. 80 93.3 N.A. 0 66.6 60 6.6 N.A. 33.3 6.6 20 0
P-Site Similarity: 100 93.3 100 93.3 N.A. 93.3 100 N.A. 13.3 73.3 73.3 20 N.A. 46.6 13.3 26.6 6.6
Percent
Protein Identity: N.A. 31.7 N.A. 26 33.9 N.A.
Protein Similarity: N.A. 50.1 N.A. 40.4 51.6 N.A.
P-Site Identity: N.A. 6.6 N.A. 0 0 N.A.
P-Site Similarity: N.A. 13.3 N.A. 13.3 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 6 6 0 6 0 0 0 18 12 6 0 0 0 0 % A
% Cys: 6 0 0 0 0 0 0 0 0 6 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 6 12 0 0 0 0 6 % D
% Glu: 18 6 0 0 12 12 6 6 6 0 6 6 6 6 42 % E
% Phe: 0 6 0 0 0 0 6 0 0 0 0 0 0 0 6 % F
% Gly: 0 6 6 0 0 0 0 12 0 0 6 12 53 6 12 % G
% His: 0 0 6 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 6 0 0 0 0 0 6 0 0 6 0 0 % I
% Lys: 0 12 0 0 53 12 0 12 0 6 0 48 12 0 0 % K
% Leu: 6 0 18 24 6 0 53 12 0 42 6 0 6 18 6 % L
% Met: 0 6 0 0 0 0 6 6 6 6 6 0 0 0 0 % M
% Asn: 0 6 30 0 0 6 12 6 0 6 53 12 0 0 0 % N
% Pro: 42 6 6 6 6 59 6 0 0 0 6 6 0 18 18 % P
% Gln: 12 6 0 0 0 0 0 0 6 0 0 0 0 24 0 % Q
% Arg: 12 0 0 53 6 0 6 0 0 0 0 12 0 6 6 % R
% Ser: 6 42 12 6 6 0 0 6 6 6 0 0 12 6 0 % S
% Thr: 0 0 6 0 0 0 0 42 6 0 0 0 0 6 6 % T
% Val: 0 0 12 6 6 6 6 0 48 0 12 0 6 12 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 6 0 0 0 0 0 6 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _